Mass General Brigham

The eMERGE program at Mass General Brigham
is led by

Dr. Elizabeth Karlson
Dr. Elizabeth is a Professor of Medicine at Harvard Medical School, Scientific Director of Mass General Brigham Personalized Medicine, and a rheumatologist and epidemiologist at Brigham and Women’s Hospital. Dr. Karlson has played leadership roles in numerous multi-institutional research projects including the Mass General Brigham Biobank, the eMERGE (electronic Medical Records and Genomics Consortium) Clinical Center at Mass General Brigham, the All of Us Research Program, and the Post-Acute Sequela of SARS-CoV2 Data Resource Core (PASC-DRC). She serves as Director of the Rheumatic Disease Epidemiology Research Program for the Section of Clinical Sciences, Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital. Dr. Karlson’s research is focused on patient-oriented and translational research including disease epidemiology, genetics, biobanking, and the use of bioinformatics to define phenotypes in the EHR. She has served on grant review committees for the National Institutes of Health, Arthritis Foundation, and national grant agencies in Canada and Europe. She has served on the American College of Rheumatology Blue Ribbon Panel on Academic Rheumatology. As a dedicated mentor, Dr. Karlson has supervised and mentored 25 trainees, of whom 20 hold appointments at academic institutions, 6 have received NIH K awards, 14 have received career development awards, and 6 have received NIH R01 grants. She has received the Henry Kunkel Young Investigator Award, the Excellence in Investigative Mentoring Award from the American College of Rheumatology, and the Senior Faculty Mentoring Award from the Brigham and Women’s Hospital.

Dr. Jordan W. Smoller

Dr. Jordan W. Smoller
Dr. Jordan W. Smoller is a psychiatrist, epidemiologist, and geneticist whose research focus has been understanding the genetic and environmental determinants of psychiatric disorders across the lifespan and using big data to advance precision mental health including improved methods to reduce risk and enhance resilience. Dr. Smoller is the Massachusetts General Hospital (MGH) Trustees Endowed Chair in Psychiatric Neuroscience, Professor of Psychiatry at Harvard Medical School and Professor in the Department of Epidemiology at the Harvard T.H. Chan School of Public Health in Boston. He is Associate Chief for Research in the MGH Department of Psychiatry, Director of the Center for Precision Psychiatry, and Director of the Psychiatric and Neurodevelopmental Genetics Unit in the MGH Center for Genomic Medicine. Dr. Smoller is a Tepper Family MGH Research Scholar and also serves as Director of the Omics Unit of the MGH Division of Clinical Research and co-Director of the Mass General Brigham Biobank at MGH. He is also co-Director of the Mass General Brigham (T32) Training Program in Precision and Genomic Medicine, an Associate Member of the Broad Institute, and President of the International Society of Psychiatric Genetics. He has played a leading role in national and international efforts to advance precision medicine. In addition to serving as a Principal Investigator (PI) in the eMERGE network, he is a PI of the PsycheMERGE Consortium and the New England Precision Medicine Consortium as part of the NIH All of Us Research Program. Dr. Smoller is an author of more than 400 scientific publications.

Dr. Shawn Murphy

Dr. Shawn Murphy
Dr. Shawn Murphy is the Chief Research Information Officer at Mass General Brigham, is a Professor of Neurology and Biomedical Informatics at Harvard Medical School, and serves as Co-Director of the Center for Innovation in Digital Healthcare at the Massachusetts General Hospital. He received his BS in Chemistry from the University of Notre Dame, and his Ph.D. in Pharmacology and Physiology and MD from the University of Chicago. Dr. Murphy’s research interests include the creation of query methods for healthcare data that enable them to be directly used by scientists even when the data is extremely large. Dr. Murphy was an inventor of Informatics for Integrating Biology and the Bedside (i2b2), a high impact and widely accepted open-source project that focuses on the integration of highly diverse phenotypic, imaging, and genomic data such that new discoveries can be visualized and produced from secondary use of routinely collected healthcare data and be applied to new methods of providing clinical decision and trial support in a learning healthcare system.